Pre-Screening of Manuscripts : A number of articles submitted / being submitted to the “Bioinformatics Trends” may not fall under its scope. The articles may not be having a minimum scientific standard that is normally required to grade a submission worth considering for onward detailed review. The submission instead may suit well for its publication in a different category of document, namely a Newsletter or Newspaper etc. It may be containing obsolete information, hence may not be graded as worthy for publication in the initial screening stage itself by the Editors/Reviewers. Editors/Reviewers role Editors/Reviewers of “Bioinformatics Trends” are empowered to exercise the pre-screening. The said pre-screening by only one editor (reviewer) may be taken as conclusive to determine the suitability/non suitability of a manuscript to push it forward for detailed review (main screening) or reject it in the said initial screening process. Editors may seek the assistance/opinion from the “Bioinformatics Trends” en-listed Referees in this process also. “Bioinformatics Trends” Publication management team or administrators may witness the status of a manuscript and the comments received by it in this process, through respective manuscript management modules. Authority to give the final negative verdict, supported by relevant and precise comments however lies on the concerned Editor only. In case a manuscript withstands the prescreening test, it follows the onward process of a detailed review (main Screening). No comments are required in this case. The Editor in the pre-screening web page has only to set the Pre-Screening out-come option to pass. These prescreened manuscripts are now available for selection by same or different editors for detailed review (main screening). Editor may offer aforesaid negative precise comments on-line in support of his/her decision on pre-screening. “Bioinformatics Trends” Publication management team/administrators and the author(s) may witness the current status and comments through their respective manuscript management modules. Alternatively, the Editor may pass-on the said comments to the Publication management team of “Bioinformatics Trends” through issue of an email. The later, in turn forwards these comments to the Author.