General Yardsticks on suitability of Manuscript : Originality- Novel that has potential to significantly add/support the research already published/known to us through available literature. Subject relevance and scientific reliability. Importance in terms of application or otherwise to scientific/business community in particular and the society in general of the subject dealt. Adequacy of abstract, key words. Appropriateness of approach or experimental design, adequacy of experimental techniques (including statistics where appropriate, need for statistical assessment). Methods adequately described/ appropriate or not. Results relevant to the problem posed/credible or not. Answers to questions: Soundness of conclusions and interpretation, interpretation and conclusions warranted by the data, reasonable speculation and clarity of the message. Relevance of citations and their up to date inclusion. Obvious omission(s) if any. Relevance of the figures and table, clarity of legends and titles. Suitability for the “Bioinformatics Trends” in totality. Its appropriateness for general readers or for a specialist clientele. Ethical issues. Presentation in toto, considering writing style, clarity in expression. (In preparation of these norms, the information provided in the guidelines of Council of Science Editors has been used.)